Carfilzomib package insert pdf in word

Gardasil is a vaccine indicated in girls and women 9 through 26 years of age for the prevention of the following diseases caused by. Once weekly versus twice weekly carfilzomib dosing in patients with relapsed and refractory multiple myeloma a. Prior approval is required to ensure the safe, clinically appropriate and cost effective use of kyprolis while maintaining optimal therapeutic outcomes 1. The reconstituted concentration of bortezomib for subcutaneous administration 2. If needed, give an additional 250 ml to 500 ml of intravenous fluids following kyprolis administration. Administration kyprolis can be administered in a 50ml or 100ml intravenous bag of 5% dextrose injection, usp. Carfilzomib, lenalidomide, and dexamethasone in new multiple. Insert an object in word or outlook office support.

Infuse over 10 or 30minutes depending on the kyprolis dose regimen see dosage and administration 2. The fda also approved kyprolis as a single agent for the treatment of patients with relapsed or refractory myeloma who have received. Erbitux can cause serious and fatal infusion reactions. Kyprolis vials contain no antimicrobial preservatives and are intended for single dose only. Then click from file on the left side of the dialog box that opens if you prefer to insert a link to andor icon of the file, rather than the entire document, click options on the left side of the dialog box and check link to file andor display as icon. Follow applicable special handling and disposal procedures. Kyprolis vials contain no antimicrobial preservatives and are intended for singledose only. Extravasation of etopophos may result in swelling, pain, cellulitis, and necrosis including skin necrosis. See the respective package inserts for vzig and ig. Kyprolis 10 mg powder in singledose vial for injection.

In the text group click the dropdown arrow for object and select object. Kyprolis carfilzomib for relapsed multiple myeloma. Kyprolis with dexamethasone and lenalidomide kyprolis with dexamethasone and cyclophosphamide for nontransplant candidates b. Embed pdf in word embed a pdf document into microsoft word. If lenalidomide is used during pregnancy, it may cause birth defects or embryofetal death.

This means that kyprolis will be given to you on days 1, 2, 8, 9, 15, and 16 of each 28day cycle. The orr in the highest dosage cohort n 48 was 75% see table 3. Kyprolis is a proteasome inhibitor indicated for the treatment of patients with multiple myeloma who have received at. Highlights of prescribing information these highlights. Kyprolis carfilzomib is a prescription medication used to treat patients with relapsed or refractory multiple myeloma who have received one to three previous treatments for multiple myeloma. Kyprolis is given 2 days in a row each week, for 3 weeks, followed by one week without treatment. Highlights of prescribing information these highlights do not include all the information needed to use empliciti safely and effectively. Authorization of 6 months may be granted for members prescribed kyprolis for the treatment of previously treated, relapsed, progressive, or refractory multiple myeloma in one of the following regimens. Highlightsof prescribing information kyprolis safely and. The program used to create this object is acroexch. Trouble inserting pdf file into ms word 2010 microsoft. Hydrate patients to reduce the risk of renal toxicity and of tumor lysis syndrome tls.

The object dialog box will appear select create from file. Pdf on may 20, 2018, ajai chari and others published daratumumab dara in combination with carfilzomib and dexamethasone dkd in lenalidomide lenrefractory patients pts with relapsed. Structure of carfilzomib excerpted from the kyprolistm u. Withhold kyprolis for grade 3 or 4 cardiac adverse events until recovery, and consider whether to restart kyprolis at 1 dose level reduction based on a benefitrisk assessment. This will allow quick identification of new safety information. Kyprolis carfilzomib rationale for inclusion in pa. Do not mix with or administer as an infusion with other medicinal products. Administer kyprolis at a starting dose of 20 mgm2 in cycle 1 on day 1. While adequate hydration is required prior to each dose in cycle 1, monitor all patients for evidence of volume overload, especially patients at risk for cardiac failure. Unopened vials of kyprolis are stable until the date indicated on the package when stored in the original package at 2c to 8c 36f to 46f. Kyprolis in combination with lenalidomide and dexamethasone. Kyprolis is indicated as a single agent for the treatment of patients with relapsed or.

Lenalidomide, a thalidomide analogue, caused limb abnormalities in a developmental monkey study similar to birth defects caused by thalidomide in humans. See full prescribing information for kyprolis carfilzomib for injection, for intravenous use initial u. Kyprolis carfilzomib kyprolis fep clinical rationale rationale for inclusion in pa program background kyprolis carfilzomib is an antineoplastic agent for the treatment of multiple myeloma in. Twentytwo rrmm pts were enrolled in the doseevaluation part and received study drug 56. Highlights of prescribing information these highlights do not include all the information needed to use cubicin safely and effectively. For the 2027 mgm2 dosage, 20 mgm2 was dosed on days 1 and 2 of cycle 1. Indications and usage highlights of prescribing information these highlights do not include all the information needed to use kyprolis safely and effectively. This will insert the pdf first page only as objects cannot span pages just as in earlier versions, without converting the pdf. Dexamethasone tablets usp, dexamethasone oral solution, and dexamethasone intensol oral solution concentrate description dexamethasone tablets 0. Graham mayor microsoft word mvp 20022019 for more word tips and downloads visit my web site. You can follow the question or vote as helpful, but you cannot reply to this thread.

Carfilzomib induced apoptosis in myeloma cell lines and primary myeloma. Phase 3 arrow study of onceweekly kyprolis carfilzomib. Information for the patient kyprolis 10 mg powder for solution for infusion kyprolis 30 mg powder for solution for infusion kyprolis 60 mg powder for solution for infusion carfilzomib this medicine is subject to additional monitoring. Highlightsof prescribing information these highlights do not include all the information needed to use kyprolis safely and effectively. Kyprolis is a proteasome inhibitor that is indicated. Pdf efficacy and safety of carfilzomib in relapsed andor refractory. Pdf objective carfilzomib carf is a secondgeneration proteasome inhibitor approved for patients with. Insert needle and inject all the liquid subcutaneously. A phase 12 study of carfilzomib in japanese patients with relapsed. Is adobe still open when youre trying to insert into word. Trouble inserting pdf file into ms word 2010 has anyone received this message while trying to insert a pdf file into a word document. Abraxane is indicated for the firstline treatment of locally advanced or metastatic nonsmall cell lung cancer, in combination with carboplatin, in patients who are not candidates for curative surgery or radiation therapy. You can help protect yourself from scammers by verifying that the contact is a microsoft agent or microsoft employee and that the phone number is an official microsoft global customer service number.

Kyprolis is indicated in combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy see clinical studies 14. Kyprolistm, carfilzomib, epoxyketone, multiple myeloma. Pdf daratumumab dara in combination with carfilzomib. For the combination regimen with lenalidomide and dexamethasone, administer kyprolis intravenously as a 10minute infusion on two consecutive days, each week for three weeks followed by a 12day rest period as shown in. For outlook, click inside of the body of an item, such as an email message or calendar event. Kyprolis is approved for use in combination with dexamethasone or with lenalidomide plus dexamethasone, which are other medicines used to treat multiple myeloma. Kyprolis carfilzomib dosing, indications, interactions. Do not mix kyprolis with or administer as an infusion with other medicinal products. Weekly carfilzomib, lenalidomide, and dexamethasone krd in. The recommended hydration includes both oral fluids 30 ml per kg at least 48 hours before cycle 1, day 1 and intravenous fluids 250 ml to 500 ml of appropriate intravenous fluid prior to each dose in cycle 1. Tech support scams are an industrywide issue where scammers trick you into paying for unnecessary technical support services. Kyprolis carfilzomib for injection, for intravenous use.

Dexamethasone should be administered prior to kyprolis to reduce the incidence and severity of infusion reactions 1. Depending on the version of word or outlook youre using, you can insert a variety of objects such as pdf files, excel charts or worksheets, or powerpoint presentations into a word document or an email message by linking or embedding them. Carfilzomib is an experimental anticancer drug that has not yet been approved for treating multiple myeloma. See full prescribing information for complete boxed warning. The reconstituted solution contains carfilzomib at. Kyprolis is administered intravenously as a 30minute infusion once weekly for three weeks followed by a day rest period as shown in table 1. Highlights of prescribing information these highlights do not include all the information needed to use revlimid safely and effectively. Open the word document and select insert on the ribbon. Tilt the upright vial and insert a syringe with appropriately sized needle into the bottom corner of the vial and remove 4ml of the reconstituted solution. Imlygictalimogene laherparepvec suspensionfor intralesionalinjection initial u. Etopophos solutions may be administered at infusion rates up to 3. Click object to insert a pdf, image, or another type of nontext file into your word document.